Map2k1 Gene Mutation

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    Our data show that the map2k1 oncogene is important in human bone formation and implicate mek1 inhibition as a potential treatment avenue for melorheostosis. Map2k1 mutations demonstrate autosomal dominant inheritance with a broad range of clinical severity both within and between families. Each mutation changes a single protein building block amino acid in mek1 protein kinase.
    map2k1 gene mutation